Pain relief in neuropathic pain-a comparison between 0.5% bupivacaine and 0.5% bupivacaine streptomycin combination

Objective: To compare the effectiveness of a combination of streptomycin and bupivacaine for the management of neuropathic pain against bupivacaine alone

Study Design: A randomized controlled double blinded trial

Place and Duration of Study: Pain clinic Combined Military Hospital [CMH] Rawalpindi, CMH Nowshera, Dermatology Dept. Military Hospital [MH] Rawalpindi, Department of Medicine, Surgery CMH Nowshera Feb 2009 to Feb 2010

Material and Methods: Fifty patients with post herpetic neuralgia [PHN], 10 patients with trigeminal neuralgia and 20 patients with nerve entrapment pain were included in the study. For each type of neuropathic pain, the patients were randomly divided into two groups. Group [B] received nerve blocks using 0.5% bupivacaine and group [BS] received nerve blocks using 0.5% bupivacaine and streptomycin Igm combination. A series of four nerve blocks on alternate days were given. VAS [Visual Analogue Scale] was recorded at four, eight and twelve weeks after the last nerve block. Mean baseline VAS and at 12 weeks post treatment in groups B and BS were compared for pain relief and the mean VAS at 12 week post treatment in both the groups was compared for the difference in pain relief between the two groups. Students't test was used for statistical analysis utilizing SPSS 10 versions

Results: Post herpetic neuralgia - group [B]: at 12 weeks, mean VAS was 5.75 in gp [B] and 2.26 in gp [BS] respectively. Nerve entrapment pain- group [B] at 12 weeks, mean VAS was 6.62 whereas in group [BS] VAS was 1.33. Trigeminal neuralgia-group [B] At 12 weeks mean VAS was 7.0. gp [BS] mean VAS was 1. Pain relief achieved was excellent

Conclusion: Streptomycin and bupivacaine combination is an effective modality to manage neuropathic pain. The pain relief achieved by streptomycin-bupivacaine combination is superior to that achieved with bupivacaine alone

Scalp as a donor site for split thickness skin grafts

Use of scalp as a donor site was reported for the first time in 1964. Since then, authors have described scalp as a donor site, which heals rapidly and re-growth of hair conceals the donor site. This study was aimed at evaluation of scalp as donor site by calculating the healing time, and frequency of post-operative complications. This was a descriptive study and was conducted at Plastic Surgery Department Jinnah Hospital, Lahore, from October, 2006 to December 2007. Thirty patients requiring split skin grafting for small to moderate sized defects [requiring up to 4 sheets] were included in this study. After taking informed consent skin graft were taken from the scalp using Zimmer Electric Dermatome. Donor site was covered with occlusive dressing. Donor site healing time and complications were recorded. Patients having scalp lesions were excluded from the study. All the patients in this study achieved healing of the donor site. None of them required grafting. 26 [86.67%] patients achieved healing by 6th post-op day.3 [10.0%] patients achieved healing by 10th postop day and the remaining 1 [3.33%] patients achieved healing by 20 days. Complications noted were folliculitis in 2 patients and scab formation in 1 patient. Alopecia, hair transplant to recipient site and hypertrophic scarring was not encountered in our study. Patients were discharged by 6th post operative day and complications were managed on outpatient basis. Overall patients' compliance and satisfaction was excellent. scalp is an excellent donor site for taking split skin graft. It has shown to be very useful in terms of quick healing, convenient post-op care and negligible complications. It should be given preference when donor site for taking skin graft is to be selected

Prevention of hypotension in caesarean delivery under spinal anaesthesia; the combination of modified supine wedged position, crystalloid co-hydration and prophylactic atropine

To evaluate the efficacy of a modified supine wedged position with table tilt, crystalloid co hydration and prophylactic intravenous atropine in the prevention of hypotension in caesarean delivery under spinal anaesthesia. Phase 2 clinical trial. Place and Duration of Study: PAF Hospital Masroor Karachi and PAF Hospital Rafiqi Shorkot Oct 2005 - April 2006. 40 parturients undergoing elective caesarean section under spinal anaesthesia were studied. Lactated Ringer's solution 10 ml/kg was administered over 10min.After Spinal in the sitting position with a 25-gauge Quincke needle using0.75% hyperbaric bupivacaine [12.75-15mg], the parturient was placed in the modified supine position with table tilt .Atropine 10microg/kg was given i/v. The baseline blood pressure and heart rate in each parturient before intervention [crystalloid co hydration, spinal, modified supine wedged position and i/v atropine] were taken as control and evaluated against the values after the intervention at different time intervals. Thirty nine out of forty patients completed the study. Mean upper sensory level was T4 at 6min post spinal. The mean spinal to delivery time was less than 12 min.5% of the parturients developed hypotension at 2 min post spinal. The mean heart rate was 96/min. The mean, systolic and diastolic blood pressures remained close to the base line values at 4, 6, 10, 12, 16 and 20 min post spinal. Modified supine wedged position with table tilt, crystalloid co-hydration and prophylactic i/v atropine is an effective combination technique which prevents spinal induced hypotension in caesarean delivery

Para-umbilical perforator based abdominal flap for forearm/hand resurfacing

A prospective study was carried out from October 1999 to December 2005 including 38 patients. The objective of the study has been to evaluate paraumblical perforator based abdominal flap for large forearm and hand defects. Prospective, interventional study. Methodology: 38 patients were evaluated for a period of six years and two months by filling a Performa which was entered in a database and different variables were evaluated. paraumblical perforator based abdominal flap is very useful for resurfacing large hand and forearm defects